Difference between revisions of "Valsartan Can Create Cancer"

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Valsartan is a popular prescription medication taken to treat hypertension and various heart issues. At the beginning of the year it was observed that certain ingredients used to manufacture Valsartan had been contaminated with NDMA. NDMA (N-nitrosodimethylamine) is known to cause cancer in humans. This information immediately prompted the FDA and European health agencies to submit worldwide safety recalls of the tainted Valsartan products.<br />About Valsartan<br />Valsartan is an antihypertensive drug that is taken for controling high blood pressure as well as for people with congestive heart issues. It’s also prescribed to patients with ventricle dysfunction after suffering a heart attack. Valsartan works by effectively blocking angiotensin II - a peptide hormone that creates constriction of the blood vessels promoting higher blood pressure. [https://www.meneolawgroup.com/dangerous-drugs/valsartan/case-evaluation valsartan cancer] made Valsartan more efficient than similar medications before it that merely worked by stopping the conversion of angiotensin I into angiotensin II (known as ACE inhibitor drugs). <br /><br />Valsartan proved to be highly effective not only for patients with high blood pressure but also people with congestive heart failure. In a recent study, Valsartan was compared with Captopril and another ACE inhibitor after a heart attack. The study determined that Valsartan was as effective as Captopril at keeping heart failure minimized. <br /><br />Yet another study found Valsartan minimized the risk of heart failure by approximately 20 percent measured against a placebo group. These results motivated the FDA to approve a label change permitting Valsartan to be prescribed by doctors for people with heart failure in addition to hypertension.<br /><br />Valsartan was initially developed by American pharmaceutical company Novartis and it was approved for use by the FDA in 1996. It was made available under the brand name Diovan prior to losing patent protection and then sold as a generic drug as valsartan. Following its launch, Valsartan rapidly became one of the most commonly taken prescription drugs in the world in the competitive blood pressure drug marketplace. In 2010, just four years after its launch, global revenue for the medication exceeded $6 billion. When the initial patent period for Valsartan expired in 2012 a number of other pharmaceutical corporations started to make generic versions of the drug. The biggest generic manufacturers of Valsartan were Teva Pharmaceuticals Industries Ltd. and Solco Healthcare Inc.<br />Contamination of Valsartan with NDMA<br />In 2018, one of the leading makers of generic valsartan, the Chinese manufacturer Zhejiang Huahai Pharmaceuticals, initially discovered that the raw Valsartan it was producing was contaminated. Zhejiang Huahai is a wholesale pharmaceutical manufacturing lab which manufactures valsartan and sells it through U.S. channels Prinston, Huahi and Solco. The company manufactures the Valsartan compound and distributes it to large pharmaceutical companies around the world who then use it to manufacture, package and market their own generic variations of Valsartan. Zhejiang Huahai was by far the biggest wholesale producer of Valsartan compound. Sometime in late June 2018, quality control tests at Zhejiang Huahai revealed that the batches of Valsartan it was manufacturing were dangerously contaminated with N-nitrosodimethylamine (NMDA). The appearance of NDMA was totally unexpected. The NDMA contamination was apparently caused by a change in the process of making the drug that Zhejiang Huahai had adopted several years before.<br /><br />The realization raised significant safety concerns because of the known dangers of NDMA. NDMA is a well-known byproduct of certain chemical manufacturing processes. NDMA is classified as a carcinogen because it is known to cause cancer in humans. Numerous animal tests have established that exposure or ingestion of simply small amounts of NDMA can cause cancer in the liver, gastrointestinal system, and in the kidneys. In the past NDMA was used in the manufacturing of rocket fuel, but this use was halted due to concerns about environmental contamination. The EPA regards NDMA as a probable human carcinogen. NDMA is regarded as a priority toxic pollutant in federal regulations. <br /><br />After realizing the NDMA contamination, Zhejiang Huahai promptly alerted pharmaceutical companies and safety agencies. This prompted the U.S. Food and Drug Administration (FDA) and European health officials to immediately recall any potentially contaminated versions of Valsartan. Since then, NDMA contamination has been found in the valsartan components made by two other pharmaceutical suppliers: Zhejiang Tianyu Pharmaceuticals of Taizhou, China; and Hetero Labs Ltd. in India. Testing on the components from those labs revealed lower levels of NDMA in relation to the Zhejiang Huahai product.<br /><br />The most effective way to highlight how serious the problem with these contaminated drugs is to show that there is wide support for continued investigation in Congress. Congress cannot agree on the hue of the sky but are in agreement that they want additional information on what occurred with Valsartan. <br />Potential Injuries from Tainted Valsartan<br />NDMA is not merely a particularly dangerous carcinogen, but it might additionally be a poison at high levels. There have been many reported issues in which people died from internal bleeding and significant liver damage after taking high doses of NDMA on just one occasion. In animal testing, taking high to moderate amounts of NDMA caused major liver damage after only a few days and cancer after only a few months. <br /><br />An investigation into the cause of the NDMA contamination has revealed that it was probably created by an alteration in the manufacturing process that Zhejiang Huahai began many years ago. This means that Valsartan tainted with NDMA was sold for many years prior to discovery and recall. This is extremely troubling because Valsartan is used as a maintenance medication which is ingested daily on a continuing basis. This means that some patients might have been ingesting NDMA once or twice a day for several years. This type of sustained long-term use is specifically the type of exposure that may cause cancer. NDMA exposure is linked to specific cancers such as:<br />Liver Cancer<br />Gastric Cancer<br />Colorectal Cancer<br />Kidney Cancer<br /><br />Given the global ingestion of Valsartan, the amount of people who could suffer from cancer from exposure to NDMA is extremely large.<br /><br />What Valsartan Users Might Need to Know<br />If you have been taking Valsartan for symptoms of hypertension or other issues, you can immediately consult with your prescribing doctor about the potential dangers to your wellness. You should also find out what generic version of Valsartan you were getting from your pharmacy. Not all generic versions of Valsartan were tainted with NDMA, although the list keeps growing as the research proceeds. In the U.S. the safety recall only applied to the Valsartan manufactured by Solco Healthcare, Teva Pharmaceutical, and Major Pharmaceuticals.<br /><br />How Much Money May You Anticipate from a Valsartan Settlement?<br />Of course, affected people want to know what the possible settlement amount of the Valsartan case can be. It’s a good question. The suffering users may endure is significant and money compensation is all we have to reach to justice. The Valsartan lawsuits are just too new to gauge the possible settlement value of these claims. We will understand more as the litigation progresses. One note to settlement value is to have lawyers who are going after every potential dollar and are determined to maximize the value of your case for all that you have had to live with either as a victim or surviving family member.<br />
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Valsartan is a popular prescription medication taken to control hypertension and other heart issues. At the beginning of the year it was observed that some ingredients used to produce Valsartan were contaminated with NDMA. NDMA (N-nitrosodimethylamine) is known to create cancer in humans. This information immediately motivated the FDA and European health officials to issue worldwide safety recalls of the contaminated Valsartan products.<br />About Valsartan<br />Valsartan is an antihypertensive drug that is used for the treatment of high blood pressure and for people with congestive heart issues. It is also prescribed to individuals with ventricle dysfunction after experiencing a heart attack. Valsartan works by effectively blocking angiotensin II - a peptide hormone that causes constriction of the blood vessels leading to higher blood pressure. The mechanism made Valsartan more effective than similar drugs before it that only worked by blocked the conversion of angiotensin I into angiotensin II (known as ACE inhibitor drugs). <br /><br />Valsartan proved to be highly effective not only for patients with high blood pressure but additionally people with congestive heart failure. In a study, Valsartan was compared with Captopril and another ACE inhibitor post heart attack. The study found that Valsartan was as effective as Captopril at keeping heart failure at bay. <br /><br />Another study found Valsartan reduced the risk of heart failure by some 20 percent compared to a placebo group. These results led the FDA to approve a label adjustment allowing Valsartan to be used by doctors for people with heart failure as well as hypertension.<br /><br />Valsartan was originally developed by American pharmaceutical giant Novartis and it was approved for use by the FDA in 1996. It was marketed under the brand name Diovan prior to losing patent protection and being marketed as a generic medication as valsartan. Following its release, Valsartan rapidly established itself as one of the most widely taken prescription drugs globally in the competitive blood pressure medication market. In 2010, only four years after its launch, worldwide sales for the medication exceeded $6 billion. When the original patent protection for Valsartan expired in 2012 a number of other pharmaceutical corporations started to make generic variations of the medication. The biggest generic manufacturers of Valsartan were Teva Pharmaceuticals Industries Ltd. and Solco Healthcare Inc.<br />Contamination of Valsartan with NDMA<br />In 2018, one of the leading makers of generic valsartan, the Chinese manufacturer Zhejiang Huahai Pharmaceuticals, first discovered that the raw Valsartan it was manufacturing was contaminated. Zhejiang Huahai is a wholesale pharmaceutical manufacturing laboratory that makes valsartan and distributes it through U.S. affiliates Prinston, Huahi and Solco. The company manufactures the Valsartan compound and wholesales it to large pharmaceutical companies globally who then use it to make, package and sell their own generic variations of Valsartan. Zhejiang Huahai was by far the largest wholesale manufacturer of Valsartan compound. During late June 2018, quality control tests at Zhejiang Huahai revealed that the batches of Valsartan it was producing were dangerously contaminated with N-nitrosodimethylamine (NMDA). The inclusion of NDMA was entirely unexpected. The NDMA contamination was obviously possible from a change in the process of synthesizing the drug that Zhejiang Huahai had chosen many years before.<br /><br />The realization created significant safety concerns because of the known dangers of NDMA. NDMA is a well-known byproduct of certain chemical manufacturing processes. NDMA is classified as a carcinogen because it is known to cause cancer in humans. Numerous animal studies have established that exposure or ingestion of even tiny amounts of NDMA might cause cancer in the liver, gastrointestinal system, and in the kidneys. In the past NDMA was used in the making of rocket fuel, but this use was halted due to issues regarding environmental contamination. The EPA classifies NDMA as a probable human carcinogen. NDMA is regarded as a priority toxic pollutant in federal regulations. <br /><br />After uncovering the NDMA contamination, Zhejiang Huahai immediately notified pharmaceutical brands and safety agencies. This prompted the U.S. Food and Drug Administration (FDA) and European health agencies to immediately recall any possibly contaminated versions of Valsartan. Since that time, NDMA contamination has been found in the valsartan components made by 2 other pharmaceutical wholesalers: Zhejiang Tianyu Pharmaceuticals of Taizhou, China; and Hetero Labs Ltd. in India. Testing on the components from these laboratories revealed lower levels of NDMA compared to the Zhejiang Huahai product.<br /><br />The best way to state how serious the issue with these contaminated medications is to show that there is bipartisan support for further investigation in Congress. These people can’t agree on the color of the sky but they agree that they need additional information on what occurred with Valsartan. <br />Potential Harm from Tainted Valsartan<br />NDMA is not merely a particularly dangerous carcinogen, but it may also be a poison at high levels. There have been several reported issues in which people died from internal bleeding and significant liver damage after ingesting high doses of NDMA on merely one occasion. In animal testing, taking high to moderate levels of NDMA caused major liver damage after just a few days and cancer after just a few months. <br /><br />An investigation about the cause of the NDMA contamination has revealed that it was most likely caused by an alteration in the manufacturing method that Zhejiang Huahai started a few years ago. [https://www.meneolawgroup.com/dangerous-drugs/valsartan/case-evaluation valsartan colon cancer] means that Valsartan tainted with NDMA was marketed for several years before observation and recall. This is extremely troubling because Valsartan is used as a maintenance medication which is taken daily on a continuing manner. This means that some patients may have been taking NDMA once or twice a day for many years. This type of continuous long-term ingestion is exactly the type of exposure that may cause cancer. NDMA exposure is linked to specific cancers such as:<br />Liver Cancer<br />Gastric Cancer<br />Colorectal Cancer<br />Kidney Cancer<br /><br />Given the widespread use of Valsartan, the amount of patients who could develop cancer from exposure to NDMA is extremely large.<br /><br />What Valsartan Users Should to Know<br />If you have been taking Valsartan for symptoms of hypertension or other conditions, you can immediately consult with your prescribing physician about the possible dangers to your health. You should also determine what generic version of Valsartan you were getting from your pharmacy. Not every generic versions of Valsartan were contaminated with NDMA, although the list continues to grow as the research continues. In the U.S. the safety recall only applied to the Valsartan made by Solco Healthcare, Teva Pharmaceutical, and Major Pharmaceuticals.<br /><br />What Amount of Money May You Expect from a Valsartan Settlement?<br />Understandably, affected people would like to know what the potential settlement amount of the Valsartan case may be. It is a valid question. The suffering victims may experience is significant and money compensation is all we have to strive towards justice. The Valsartan lawsuits are simply too recent to observe the possible settlement value of these claims. We will understand more as the litigation continues. One key to settlement amount is to have lawyers that are fighting for every potential penny and are fighting to maximize the value of your case for all that you have had to live with either as a victim or surviving family member.<br />

Latest revision as of 01:11, 15 January 2020

Valsartan is a popular prescription medication taken to control hypertension and other heart issues. At the beginning of the year it was observed that some ingredients used to produce Valsartan were contaminated with NDMA. NDMA (N-nitrosodimethylamine) is known to create cancer in humans. This information immediately motivated the FDA and European health officials to issue worldwide safety recalls of the contaminated Valsartan products.
About Valsartan
Valsartan is an antihypertensive drug that is used for the treatment of high blood pressure and for people with congestive heart issues. It is also prescribed to individuals with ventricle dysfunction after experiencing a heart attack. Valsartan works by effectively blocking angiotensin II - a peptide hormone that causes constriction of the blood vessels leading to higher blood pressure. The mechanism made Valsartan more effective than similar drugs before it that only worked by blocked the conversion of angiotensin I into angiotensin II (known as ACE inhibitor drugs).

Valsartan proved to be highly effective not only for patients with high blood pressure but additionally people with congestive heart failure. In a study, Valsartan was compared with Captopril and another ACE inhibitor post heart attack. The study found that Valsartan was as effective as Captopril at keeping heart failure at bay.

Another study found Valsartan reduced the risk of heart failure by some 20 percent compared to a placebo group. These results led the FDA to approve a label adjustment allowing Valsartan to be used by doctors for people with heart failure as well as hypertension.

Valsartan was originally developed by American pharmaceutical giant Novartis and it was approved for use by the FDA in 1996. It was marketed under the brand name Diovan prior to losing patent protection and being marketed as a generic medication as valsartan. Following its release, Valsartan rapidly established itself as one of the most widely taken prescription drugs globally in the competitive blood pressure medication market. In 2010, only four years after its launch, worldwide sales for the medication exceeded $6 billion. When the original patent protection for Valsartan expired in 2012 a number of other pharmaceutical corporations started to make generic variations of the medication. The biggest generic manufacturers of Valsartan were Teva Pharmaceuticals Industries Ltd. and Solco Healthcare Inc.
Contamination of Valsartan with NDMA
In 2018, one of the leading makers of generic valsartan, the Chinese manufacturer Zhejiang Huahai Pharmaceuticals, first discovered that the raw Valsartan it was manufacturing was contaminated. Zhejiang Huahai is a wholesale pharmaceutical manufacturing laboratory that makes valsartan and distributes it through U.S. affiliates Prinston, Huahi and Solco. The company manufactures the Valsartan compound and wholesales it to large pharmaceutical companies globally who then use it to make, package and sell their own generic variations of Valsartan. Zhejiang Huahai was by far the largest wholesale manufacturer of Valsartan compound. During late June 2018, quality control tests at Zhejiang Huahai revealed that the batches of Valsartan it was producing were dangerously contaminated with N-nitrosodimethylamine (NMDA). The inclusion of NDMA was entirely unexpected. The NDMA contamination was obviously possible from a change in the process of synthesizing the drug that Zhejiang Huahai had chosen many years before.

The realization created significant safety concerns because of the known dangers of NDMA. NDMA is a well-known byproduct of certain chemical manufacturing processes. NDMA is classified as a carcinogen because it is known to cause cancer in humans. Numerous animal studies have established that exposure or ingestion of even tiny amounts of NDMA might cause cancer in the liver, gastrointestinal system, and in the kidneys. In the past NDMA was used in the making of rocket fuel, but this use was halted due to issues regarding environmental contamination. The EPA classifies NDMA as a probable human carcinogen. NDMA is regarded as a priority toxic pollutant in federal regulations.

After uncovering the NDMA contamination, Zhejiang Huahai immediately notified pharmaceutical brands and safety agencies. This prompted the U.S. Food and Drug Administration (FDA) and European health agencies to immediately recall any possibly contaminated versions of Valsartan. Since that time, NDMA contamination has been found in the valsartan components made by 2 other pharmaceutical wholesalers: Zhejiang Tianyu Pharmaceuticals of Taizhou, China; and Hetero Labs Ltd. in India. Testing on the components from these laboratories revealed lower levels of NDMA compared to the Zhejiang Huahai product.

The best way to state how serious the issue with these contaminated medications is to show that there is bipartisan support for further investigation in Congress. These people can’t agree on the color of the sky but they agree that they need additional information on what occurred with Valsartan.
Potential Harm from Tainted Valsartan
NDMA is not merely a particularly dangerous carcinogen, but it may also be a poison at high levels. There have been several reported issues in which people died from internal bleeding and significant liver damage after ingesting high doses of NDMA on merely one occasion. In animal testing, taking high to moderate levels of NDMA caused major liver damage after just a few days and cancer after just a few months.

An investigation about the cause of the NDMA contamination has revealed that it was most likely caused by an alteration in the manufacturing method that Zhejiang Huahai started a few years ago. valsartan colon cancer means that Valsartan tainted with NDMA was marketed for several years before observation and recall. This is extremely troubling because Valsartan is used as a maintenance medication which is taken daily on a continuing manner. This means that some patients may have been taking NDMA once or twice a day for many years. This type of continuous long-term ingestion is exactly the type of exposure that may cause cancer. NDMA exposure is linked to specific cancers such as:
Liver Cancer
Gastric Cancer
Colorectal Cancer
Kidney Cancer

Given the widespread use of Valsartan, the amount of patients who could develop cancer from exposure to NDMA is extremely large.

What Valsartan Users Should to Know
If you have been taking Valsartan for symptoms of hypertension or other conditions, you can immediately consult with your prescribing physician about the possible dangers to your health. You should also determine what generic version of Valsartan you were getting from your pharmacy. Not every generic versions of Valsartan were contaminated with NDMA, although the list continues to grow as the research continues. In the U.S. the safety recall only applied to the Valsartan made by Solco Healthcare, Teva Pharmaceutical, and Major Pharmaceuticals.

What Amount of Money May You Expect from a Valsartan Settlement?
Understandably, affected people would like to know what the potential settlement amount of the Valsartan case may be. It is a valid question. The suffering victims may experience is significant and money compensation is all we have to strive towards justice. The Valsartan lawsuits are simply too recent to observe the possible settlement value of these claims. We will understand more as the litigation continues. One key to settlement amount is to have lawyers that are fighting for every potential penny and are fighting to maximize the value of your case for all that you have had to live with either as a victim or surviving family member.

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