In , medical examinations see above and thyroid assessments had been performed with of presumably active plant workers men and 33 girls. Flaked resorcinol triggered no perceptible to reasonable irritation intact skin or no perceptible necrosis abraded pores and skin.
The effects have been more pronounced at 72 h. The irritation index was given as 4. However, owing to lacking correlating Come bloccare un pignoramento immobiliare in the three ranges of the brain examined and in the absence of a dose—response relationship, other indicators of developmental delay, or different changes in CNS function, these results weren't considered as conclusive evidence of a change in CNS function. In the next two-generation reproductive toxicity study RTF, , these finish-points weren't investigated. No resorcinol-associated results on F 0 and F 1 pup survival or the final bodily situation of the pups in the course of the pre-weaning interval have been noticed.
Verifica dellappartenenza dei beni nelle process esecutive. La provenienza successoria of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there are no epidemiological information related to the carcinogenicity of resorcinol in humans and that the evidence of its carcinogenicity in animals is insufficient; thus, resorcinol isn't classifiable as to its carcinogenicity to people. JECFA assessed the hazards from the use of resorcinol as a meals flavouring agent and concluded that this use is of no safety concern. Overall, the research usually are not adequate for a statistical extrapolation method based on the EU Technical Guidance Document EC, a.
- However, Asta giudiziaria is questionable for use as a restrict worth in risk evaluation this is the highest concentration tested in this examine , and the NOEC might be significantly greater than stated in the study.
- Resorcinol showed a focus-dependent improve in labelling index [ 3 H]thymidine , acanthosis, and papillomatosis.
- No resorcinol-related macroscopic findings, organ weight, or antagonistic microscopic target organ effects had been observed in the F 0 and F 1 parental animals.
- No other biologically vital variations in organ weights had been noticed.
- In controls and the excessive-dose group, a qualitative histopathological evaluation of the brain forebrain, midbrain, and hindbrain was also performed for the aforementioned animals RTF, There were no adverse results regarding reproductive efficiency, mortality, and body or organ weights.
- Formulations tested in the key studies anti-pimples cream and hair dye have in all probability changed during the last 20 or more years.
Different studies performed with rats and mice gave no improve within the micronucleus formation in bone marrow cells. Bone marrow smears had been prepared at 30 h, and polychromatic erythrocytes per animal were scored Gocke et al. An interim sacrifice at 15 months gave no difference in haematology, clinical chemistry, or different medical pathology parameters and no elevated incidence of neoplasms or non-neoplastic lesions. Also, at ultimate sacrifice, there was no evidence of carcinogenic exercise in males or females of each species.
In each species, there were no opposed results on final mean physique weights, haematology, or clinical chemistry parameters, and no chemical-related gross or microscopic lesions had been noticed. In another examine, rats have been uncovered to 0 or 0. No thyroid hormone measurements had been performed.
In one other examine, male F rats have been handled with three intraperitoneal injections of three-methyl-. Based on the examine of Yeung et al.
The elimination was biphasic, with half-lives of 18—21 min and 8. The 14 C activity was rapidly distributed in major tissues such as muscle tissue, kidneys, and liver, with out indication of bioaccumulation Merker et al. Any new information being supplied in the middle of the OECD assessment shall be offered to the IPCS in order that an addendum may be ready for consideration.