Although thyroid results are a major end-point in each human case-research and animal studies, there's a lack of consistency in the leads to the animal studies. Resorcinol caused no adverse results in several reproduction and developmental toxicity research in rats and rabbits. Resorcinol is not thought-about to be genotoxic.
Thyroid glands from all surviving F 0 mother and father have been examined microscopically, and mind measurements had been performed on all uncovered F 1 pups and those F 1 pups chosen for behavioural testing. There were no vital sex variations. In females, a larger proportion was excreted as sulfate conjugate, whereas males excreted a higher proportion of a diconjugate both sulfate and glucuronide groups. From these information, the authors concluded that male rats have a better capacity for glucuronidation than females.
Determination of resorcinol conjugates in the h urine samples after 14 days of continuous product therapy confirmed that a maximal 23 mg 2. Assuming a body weight of sixty four kg IPCS, gives an publicity estimate of zero. In a report primarily based on consumer analysis knowledge Gans, , beneath cheap maximum-use conditions i.
In , medical examinations see above and thyroid assessments have been carried out with of presumably lively plant staff men and 33 girls. Flaked resorcinol caused no perceptible to reasonable irritation intact skin or no perceptible necrosis abraded pores and skin.
For the benthic and terrestrial compartments, the obtainable toxicity knowledge cannot be regarded as enough for a quantitative risk characterization. However, these compartments are less relevant for resorcinol, because of marginal releases and emissions to these compartments as well as a really low potential for adsorption of resorcinol to organic matter.
The bulk of the urine-recovered dye must have been taken up into the attractive layer of the skin and then slowly launched into the circulation. A cumulative 4-day absorption assuming cm 2 of scalp was given as zero.
- For the toxicity to aquatic crops, no guideline study is available.
- In a study carried out by NTP , five male and female F rats were dosed with resorcinol in deionized water via gavage at zero, High-dose females had significantly decreased absolute and relative thymus weights.
- For the thyroid, a non-statistically significant improve in TSH levels was reported for interim males, but not at scheduled necropsy.
- The effects had been extra pronounced at 72 h.
- Although thyroid results are a major finish-level in both human case-research and animal studies, there's a lack of consistency in the leads to the animal studies.
- In plasma, the T four half-life is about 12—24 h in rats vs 5—9 days in people, and the serum ranges of TSH are about 25 instances greater in rodents than in humans.
- Most of the studies are of enough high quality and acceptable for threat characterization purposes.
- In rodents, the upper sensitivity is also associated to a shorter plasma half-lifetime of T four than in humans as a result of considerable variations between species within the transport proteins for thyroid hormones.
Experimental data on soil sorption using silty loam point out a very low potential for geoaccumulation. However, the exposed space cm 2 was greatly in extra of the common space of skin usually handled for zits. Formulations tested in the key studies anti-acne cream and hair dye have in all probability modified during the last 20 or extra years. Resorcinol enters the setting primarily during its utilization in consumer merchandise hair dyes and pharmaceuticals. In addition, localized high concentrations can appear in coal conversion wastewater or in wastewater in areas with oil shale mining.
The organisms were uncovered to the take a look at concentrations for 96 h. Biological observations have been performed day by day.
More ordinary-use situations would result in exposures of about zero. Further details were not given.
Other pores and skin effects were hyperplasia, hyperkeratosis, irritation, and sebaceous gland hyperplasia, whereas there have been no systemic therapy-related lesions. With resorcinol, several initiation—promotion research with hamsters Maruyama et al. Female Syrian golden hamsters 10—20 per group had been handled with two subcutaneous injections of. In a research carried out by Hasegawa et al.
The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and treated pores and skin areas showed slight erythema and extreme dryness. Mean information for 3 donors and sixteen replicates point out a plateau in receptor fluid concentration between 24 and 48 h, as reflected by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats strain not given;.
There had been no published animal research exhibiting thyroidal results with a dose—response relationship that could be used for a tolerable intake. In the frame of a full life cycle toxicity take a look at OECD TG , Lima noticed no antagonistic results after forty eight h of exposure on the highest concentration tested, zero. Furthermore, Cronin et al. The fish and pond snails had been placed instantly into the aquaria, while the remaining five species had been segregated in different baskets and suspended within the aquaria. The only investigation into this finish-level is that from the dose vary-discovering study reported in sections eight.