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The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and handled skin areas showed slight erythema and extreme dryness. Mean information for 3 donors and sixteen replicates point out a plateau in receptor fluid focus between 24 and 48 h, as mirrored by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats pressure not given;.
The elimination was biphasic, with half-lives of 18—21 min and 8. The 14 C exercise was rapidly distributed in major tissues similar to muscular tissues, kidneys, and liver, without indication of bioaccumulation Merker et al. Any new data being supplied in the midst of the OECD evaluation will be supplied to the IPCS so that an addendum could be ready for consideration.
Furthermore, continual research with fish and Daphnia have been performed. For the toxicity to aquatic vegetation, no guideline study is out there. However, bearing in mind the available studies for toxicity to aquatic vegetation, the NOEC for algae could be assumed to be higher than that for Daphnia magna. Exposure to resorcinol by the use of peeling agents presents an acute publicity state of affairs the place the person is uncovered to a excessive focus 7. Acute effects have been described beneath these circumstances.
Thyroid glands from all surviving F 0 parents had been examined microscopically, and mind measurements were performed on all exposed F 1 pups and those F 1 pups chosen for behavioural testing. There have been no important sex differences. In females, a higher proportion was excreted as sulfate conjugate, whereas males excreted a higher proportion of a diconjugate each sulfate and glucuronide teams. From these information, the authors concluded that male rats have a higher capacity for glucuronidation than females.
The third study, performed in , included of energetic workers. In subjects men, thirteen women with a imply age of 37 years, each laboratory and other checks, together with medical examination, have been carried out; no abnormal thyroid glands or modifications in T four values were found in any of the subjects compared with regular values Bauer, The above data are limited because of small study sizes, lack of comparability teams, lacking current and historical control knowledge, and lacking information regarding potential exposure categories. In a study in a plant producing resorcinol by sulfonation of benzene — and in addition producing beta -resorcylic acid, resorcinol—formaldehyde resins, sulfites, and sulfates — employees have been uncovered primarily to resorcinol, but the publicity to other brokers was not measured for exposure ranges, see section 6. In this plant, three cross-sectional studies had been carried out between and Flickinger, In , medical examinations, chest X-rays, pulmonary operate, haematology, and scientific chemistry were performed with of individuals actively employed at a manufacturing plant in Pennsylvania, USA. In addition, male rats have higher circulating ranges of TSH than females.
There have been no revealed animal research displaying thyroidal effects with a dose—response relationship that might be used for a tolerable consumption. In the body of a full life cycle toxicity take a look at OECD TG , Lima noticed no adverse results after 48 h of publicity on the highest focus tested, 0. Furthermore, Cronin et al. The fish and pond snails had been positioned instantly into the aquaria, whereas the remaining 5 species have been segregated in several baskets and suspended within the aquaria. The solely investigation into this end-level is that from the dose vary-discovering examine reported in sections eight.

In each species, there have been no adverse results on last imply body weights, haematology, or clinical chemistry parameters, and no chemical-associated gross or microscopic lesions have been observed. In one other research, rats have been exposed to 0 or 0. No thyroid hormone measurements had been performed.

  • For the thyroid, a non-statistically significant enhance in TSH levels was reported for interim males, but not at scheduled necropsy.

  • The iodination process is catalysed by a haem-containing enzyme.

  • Fifty per cent of survivors had been sacrificed 1 week later, and blood and urine samples were taken.

  • A concentration of 0.

  • In both species, there have been no antagonistic effects on last imply body weights, haematology, or scientific chemistry parameters, and no chemical-associated gross or microscopic lesions were noticed.

  • Five of three.

Determination of resorcinol conjugates in the h urine samples after 14 days of steady product remedy showed that a maximal 23 mg 2. Assuming a physique weight of sixty four kg IPCS, provides an exposure estimate of zero. In a report based on client analysis data Gans, , underneath cheap maximum-use situations i.
Although thyroid results are a significant finish-point in each human case-research and animal studies, there's a lack of consistency in the leads to the animal studies. Resorcinol brought on no opposed results in a number of replica and developmental toxicity research in rats and rabbits. Resorcinol isn't thought of to be genotoxic.

There is not any guideline research on toxicity for aquatic plants available. As just one concentration was examined, the study cannot be used in the danger evaluation. There are several research out there on acute toxicity to completely different fish species.

There are variations in thyroid physiology between people and animals. The weight of proof suggests that rodents are extra sensitive to thyroid results than humans.

Other pores and skin effects were hyperplasia, hyperkeratosis, inflammation, and sebaceous gland hyperplasia, whereas there were no systemic treatment-related lesions. With resorcinol, a number of initiation—promotion research with hamsters Maruyama et al. Female Syrian golden hamsters 10—20 per group were treated with two subcutaneous injections of. In a research carried out by Hasegawa et al.
The results were extra pronounced at seventy two h. The irritation index was given as four. However, owing to missing correlating histopathological modifications in the three ranges of the mind examined and within the absence of a dose—response relationship, other indicators of developmental delay, or different changes in CNS perform, these results weren't considered as conclusive proof of a change in CNS function. In the following two-technology reproductive toxicity research RTF, , these finish-points weren't investigated. No resorcinol-associated effects on F 0 and F 1 pup survival or the overall physical condition of the pups in the course of the pre-weaning interval were noticed.
Apart from one constructive single case-study Vilaplana et al. In these circumstances, the examined concentration of resorcinol was 0. The data are summarized in Table 8. Data regarding the totally different job categories weren't offered.