Hence, an improved biodegradation rate ends in decreased dangers for the surroundings. Regarding the consequences of resorcinol on aquatic species, the toxicity information set includes quite a lot of species from different trophic levels. Results from checks with completely different aquatic species from totally different trophic ranges are available for the acute toxicity of resorcinol to aquatic organisms.
In each species, there were no opposed results on final mean body weights, haematology, or scientific chemistry parameters, and no chemical-related gross or microscopic lesions have been observed. In another examine, rats had been uncovered to 0 or zero. No thyroid hormone measurements have been performed.
British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there aren't any epidemiological information related to the carcinogenicity of resorcinol in people and that the evidence of its carcinogenicity in animals is insufficient; thus, resorcinol isn't classifiable as to its carcinogenicity to people. JECFA assessed the hazards from the use of resorcinol as a meals flavouring agent and concluded that this use is of no safety concern. Overall, the studies aren't sufficient for a statistical extrapolation approach in accordance with the EU Technical Guidance Document EC, a.
In apply, however, the incidence of sensitization seems to be low. In animal studies, the toxicological results reported to be brought on by administration of resorcinol embrace thyroid dysfunction, irritation to pores and skin and eyes, CNS effects, and altered adrenal gland relative weights. After topical use of excessive concentrations of resorcinol, CNS disturbances, similar to dizziness, vertigo, confusion, disorientation, amnesia, or tremors, or pink blood cell adjustments, corresponding to methaemoglobinaemia, haemolytic anaemia, haemoglubinuria, or cyanosis, have been reported. One issue increasing potential poisonous effects is the application of resorcinol to injured skin.
From its use in topical medication and from restricted information from occupational research, resorcinol doesn't seem like irritating to the pores and skin within the concentrations reported. Van Leeuwen et al. There is no indication as to whether the teratogenic effects have been endocrine mediated or not EC, c. In humans, dermal publicity to resorcinol has been reported to be related to thyroid effects, CNS disturbances, red blood cell adjustments, and a low incidence of skin sensitization. Five of 3.
The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and handled pores and skin areas confirmed slight erythema and extreme dryness. Mean knowledge for 3 donors and sixteen replicates point out a plateau in receptor fluid focus between 24 and forty eight h, as mirrored by cumulative absorption values of 1. A steady-state permeability coefficient. For male albino rats strain not given;.
Experimental knowledge on soil sorption utilizing silty loam point out a very low potential for geoaccumulation. However, the uncovered space cm 2 was tremendously in excess of the typical space of skin often treated for zits. Formulations tested in the key research anti-zits cream and hair dye have in all probability changed over the past 20 or more years. Resorcinol enters the surroundings mainly throughout its utilization in consumer products hair dyes and prescribed drugs. In addition, localized high concentrations can appear in coal conversion wastewater or in wastewater in regions with oil shale mining.
There are variations in thyroid physiology between humans and animals. The weight of evidence means that rodents are extra delicate to thyroid results than humans.
The elimination was biphasic, with half-lives of 18—21 min and 8. The 14 C activity was rapidly distributed in major tissues similar to muscle tissue, kidneys, and liver, without indication of bioaccumulation Merker et al. Any new data being provided in the course of the OECD evaluation might be provided to the IPCS in order that an addendum can be prepared for consideration.
Although thyroid effects are a significant end-level in both human case-studies and animal studies, there's a lack of consistency within the ends in the animal research. Resorcinol caused no antagonistic effects in a number of copy and developmental toxicity studies in rats and rabbits. Resorcinol just isn't thought-about to be genotoxic.
Apart from one constructive single case-examine Vilaplana et al. In these circumstances, the tested focus of resorcinol was zero. The knowledge are summarized in Table 8. Data in regards to the different job categories weren't offered.
Animals that died showed hyperaemia and distension of stomach and intestine, while there have been no gross lesions at necropsy in survivors Flickinger, In one other research with CFY rats. Most of the studies are of enough quality and acceptable for risk characterization functions.